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Deep learning for polygenic score analysis for Alzheimer's disease risk prediction in the Chinese populationZhou X., Chen Y., Ip F.C.F., Jiang Y., Cao H., Zhong H., Chen Y., Chen J., Zhang Y., Ma .S, Lai N.C.H., Lo R.M.N., Cheung K., Tong E.P., Mok K.Y., Hardy J., Guo Q., Mok V.C.T., Kwok T.C., Chen L., Fu A.K.Y. and Ip N.Y.
Alzheimers Dement. 2021 Dec;17 Suppl 3:e056625. doi: 10.1002/alz.056625. PMID: 35109110
[Abstract] [Full text] AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmosetGoertsen D., Flytzanis N.C., Goeden N., Chuapoco M.R., Cummins A., Chen Y., Fan Y., Zhang Q., Sharma J., Duan Y., Wang L., Feng G., Chen Y., Ip N.Y., Pickel J., Gradinaru V.
Nat Neurosci. 2021 Dec 9. doi: 10.1038/s41593-021-00969-4. PMID: 34887588
[Abstract] [Full text] A near-infrared AIE fluorescent probe for myelin imaging: From sciatic nerve to the optically cleared brain tissue in 3DWu M.Y., Wong A.Y.H., Leung J.K., Kam C., Wu K.L., Chan Y.S., Liu K., Ip N.Y. and Chen S.
Proc Natl Acad Sci U S A; 2021 Nov 9;118(45):e2106143118. doi: 10.1073/pnas.2106143118. PMID: 34740969
[Abstract] [Full text] Rhynchophylline Administration Ameliorates Amyloid-β Pathology and Inflammation in an Alzheimer's Disease Transgenic Mouse ModelFu W.Y., Hung K.W., Lau S.F., Butt B., Yuen V.W., Fu G., Chan I.C., Ip F.C.F., Fu A.K.Y. and Ip N.Y.
ACS Chem Neurosci. 2021 Nov 5. doi: 10.1021/acschemneuro.1c00600. PMID: 34738783
[Abstract] [Full text] A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in miceIp F.C.F., Fu G., Yang F., Kang F., Sun P., Ling C.Y., Cheung K., Xie F., Hu Y., Fu L. and Ip N.Y.
Eur J Med Chem. 2021 Sep 13;226:113827. doi: 10.1016/j.ejmech.2021.113827. PMID: 34530383
[Abstract] [Full text] Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in miceDuan Y., Ye T., Qu Z., Chen Y., Miranda A., Zhou X., Lok K.C., Chen Y., Fu A.K.Y., Gradinaru V. and Ip N.Y.
Nat Biomed Eng. 2021 Jul 26. doi: 10.1038/s41551-021-00759-0.PMID: 34312508
[Abstract] [Full text] IL-33/ST2 Signaling Regulates Synaptic Plasticity and Homeostasis in the Adult Hippocampal CircuitryWang Y., Fu A.K.U. and Ip N.Y.
DNA Cell Biol. 2021 Jul 22. doi: 10.1089/dna.2021.0491.
[Abstract] GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's diseaseXu P., Chang J.C., Zhou X., Wang W., Bamkole M., Wong E., Bettayeb K., Jiang L.L., Huang T., Luo W., Xu H., Nairn A.C., Flajolet M., Ip N.Y., Li Y.M., Greengard P.
J Exp Med. 2021 Aug 2;218(8):e20202446. doi: 10.1084/jem.20202446.
[Abstract] [Full text] Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and stagingJiang Y., Zhou X., Ip F.C., Chan P., Chen Y., Lai N.C.H., Cheung K., Lo R.M.N., Tong E.P.S., Wong B.W.Y., Chan A.L.T., Mok V.C.T., Kwok T.C.Y., Mok K.Y., Hardy J., Zetterberg H., Fu A.K.Y. and Ip N.Y.
Alzheimers Dement. 2021 May 25. doi: 10.1002/alz.12369.
[Abstract] [Full text] IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s DiseaseLau S.F., Chen C., Fu W.Y., Qu J.Y., Cheung T.H., Fu A.K.Y. and Ip N.Y.
Cell Rep. 2020 Apr 21;31(3):107530. doi: 10.1016/j.celrep.2020.107530.
[Abstract] [Full text] Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer's disease transgenic mouse modelLau J.K.Y., Tian M., Shen Y., Lau S.F., Fu W.Y., Fu A.K.Y. and Ip N.Y.
Sci Rep. 2021 Feb 23;11(1):4359. doi: 10.1038/s41598-021-83932-4.
[Abstract] [Full text] Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickasesYe T., Duan Y., Tsang H.W.S., Chen Y., Cao H., Chen Y., Fu A.K.Y. and Ip N.Y.
Communications Biology 4, Article number: 195 (2021)
[Abstract] [Full text] Quantitative in vivo assessment of amyloid-beta phagocytic capacity in an Alzheimer’s disease mouse modelLau S.F., Wu W., Seo H., Fu A.K.Y. and Ip N.Y.
STAR Protocols STAR Protoc. 2021 Jan 13;2(1):100265. doi: 10.1016/j.xpro.2020.100265. eCollection 2021 Mar 19.
[Abstract] [Full text] Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampusWang Y., Fu W.Y., Cheung K., Hung K.W., Chen C., Geng H., Yung W.H., Qu J.Y., Fu A.K.Y. and Ip N.Y.
Proc. Natl. Acad. Sci. USA. January 5, 2021 118 (1) e2020810118; https://doi.org/10.1073/pnas.2020810118
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