孔雀计划科研成果
  • Shen Y, Tian M, Zheng Y, Gong F, Fu AK, Ip NY. Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer's Disease Model. Cell Rep. 2016. 7(7):1819-1831.

  • Ip FC, Zhao YM, Chan KW, Cheng EY, Tong EP, Chandrashekar O, Fu GM, Zhao ZZ, Ip NY. Neuroprotective effect of a novel Chinese herbal decoction on cultured neurons and cerebral ischemic rats. BMC Complement Altern Med. 2016. 16(1):437.

  • Ip FC, Zhao YM, Chan KW, Cheng EY, Tong EP, Chandrashekar O, Fu GM, Zhao ZZ, Ip NY. Neuroprotective effect of a novel Chinese herbal decoction on cultured neurons and cerebral ischemic rats. BMC Complement Altern Med. 2016. 16(1):437.

  • Tang G, Liu X, Ma N, Huang X, Wu ZL, Zhang W, Wang Y, Zhao BX, Wang ZY, Ip FC, Ip NY*, Ye WC*, Shi L*, Chen WM*. Design and Synthesis of Dimeric Securinine Analogues with Neuritogenic Activities. ACS Chem Neurosci. 2016. 7(10):1442-1451. (*: Co-responding author)

  • Fu AK, Hung KW, Yuen MY, Zhou X, Mak DS, Chan IC, Cheung TH, Zhang B, Fu WY, Liew FY, Ip NY. IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline. Proc Natl Acad Sci U S A. 2016. 113(19):E2705-13.

  • Liang Z, Ye T, Zhou X, Lai KO, Fu AK, Ip NY. Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development. J Neurosci. 2015. 35(45):15127-34.

  • Zhang P, Fu WY, Fu AK, Ip NY. S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength. Nat Commun. 2015. 6:8665.

  • Ng YP, Or TC, Ip NY. Plant alkaloids as drug leads for Alzheimer's disease. Neurochem Int. 2015. 89:260-70.

  • Chen Y, Liang Z, Fei E, Chen Y, Zhou X, Fang W, Fu WY, Fu AK, Ip NY. Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling. PLoS One. 2015. 10(7):e0133115.

  • Ye T, Fu AK, Ip NY. Emerging roles of Axin in cerebral cortical development. Front Cell Neurosci. 2015. 9:217.

  • Yoshii A, Constantine-Paton M, Ip NY. Editorial: Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function. Front Synaptic Neurosci. 2015. 7:8.

  • Lai KO, Liang Z, Fei E, Huang H, Ip NY. Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) Is Required for Dendritic Spine Morphogenesis. J Biol Chem. 2015. 290(23):14637-46

  • Lai KO, Ip NY. Cdk5: a key player at neuronal synapse with diverse functions. Mini Rev Med Chem. 2015. 15(5):390-5.

  • Ip FC, Fu WY, Cheng EY, Tong EP, Lok KC, Liang Y, Ye WC, Ip NY. Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection. Neuropsychopharmacology. 2015. 40(8):1877-87.

  • Fu AK, Ip NY. Neddylation is needed for synapse maturation. Nat Neurosci. 2015. 18(2):164-6.

  • Zhao XS, Fu WY, Hung KW, Chien WW, Li Z, Fu AK, Ip NY. NRC-interacting factor directs neurite outgrowth in an activity-dependent manner. Neuroscience. 2015. 289:207-13.

  • Fang WQ, Chen WW, Jiang L, Liu K, Yung WH, Fu AK, Ip NY. Overproduction of upper-layer neurons in the neocortex leads to autism-like features in mice. Cell Rep. 2014. 9(5):1635-43.

  • Zhao XS, Fu WY, Chien WW, Li Z, Fu AK, Ip NY. p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1). PLoS One. 2014. 9(10):e110584.

  • Ye T, Ip JP, Fu AK, Ip NY. Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex. Nat Commun. 2014. 5:4826.

  • Ip FC, Ng YP, An HJ, Dai Y, Pang HH, Hu YQ, Chin AC, Harley CB, Wong YH, Ip NY. Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals. 2014. 22(1):52-63.

  • Fu AK, Hung KW, Huang H, Gu S, Shen Y, Cheng EY, Ip FC, Huang X, Fu WY, Ip NY. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2014. 111(27):9959-64.

  • Tang J, Ip JP, Ye T, Ng YP, Yung WH, Wu Z, Fang W, Fu AK, Ip NY. Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition. J Neurosci. 2014. 34(22):7425-36.

  • Chen Y, Ip FC, Shi L, Zhang Z, Tang H, Ng YP, Ye WC, Fu AK, Ip NY. Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton. J Neurosci. 2014. 34(7):2413-21.

  • Ip JP, Fu AK, Ip NY. CRMP2: functional roles in neural development and therapeutic potential in neurological diseases. Neuroscientist. 2014. 20(6):589-98.

  • Lai KO, Ip NY. Structural plasticity of dendritic spines: the underlying mechanisms and its dysregulation in brain disorders. Biochim Biophys Acta. 2013. 1832(12):2257-63.

  • Fang WQ, Chen WW, Fu AK, Ip NY. Axin directs the amplification and differentiation of intermediate progenitors in the developing cerebral cortex. Neuron. 2013. 79(4):665-79.

  • Chen Y, Fu AK, Ip NY. Axin: an emerging key scaffold at the synapse. IUBMB Life. 2013. 65(8):685-91.

  • Ng YP, Chen Y, Hu Y, Ip FC, Ip NY. Olean-12-eno[2,3-c] [1,2,5]oxadiazol-28-oic acid (OEOA) induces G1 cell cycle arrest and differentiation in human leukemia cell lines. PLoS One. 2013. 8(5):e63580.

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